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Recent publications

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Our Research and Development facility undertakes a variety of research projects using a broad range of scientific disciplines and collaborations.  We publish results from our research in a variety of external, peer-reviewed scientific / academic publications. Here is a brief account of our most recent publications.


Open access manuscripts are indicated with the icon OA

Next-generation tobacco and nicotine products: Substantiating harm reduction and supporting tobacco regulatory science
Toxicology Research and Application
Proctor, C. Polosa, R. Peitsch, M. Hassler, T. Gaca, M. Hill, E. Hoeng, J. Hayes, A W.
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Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity
Toxicology In Vitro
Gaca, M. et al.
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Changes in Biomarkers of Exposure on Switching From a Conventional Cigarette to Tobacco Heating Products: A Randomized, Controlled Study in Healthy Japanese Subjects
Nicotine & Tobacco Research
Gale, N. McEwan, M. Eldridge, A. Fearon, I. Sherwood, N. Bowen, E. McDermott, S. Holmes, E. Hedge, A. Hossack, S. Wakenshaw, L. Glew, J. Camacho, O. Errington, G. McAughey, J. Murphy, J. Liu, C. Proctor, C.
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Evaluation of flavourings potentially used in a heated tobacco product: Chemical analysis, in vitro mutagenicity, genotoxicity, cytotoxicity and in vitro tumour promoting activity
Food and Chemical Toxicology
Crooks, I. Neilson, L. Scott, K. Reynolds, L. Oke, T. Forster, M. Meredith, C. McAdam, K. Proctor, C.
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A mini-literature review on the science of tobacco heating product THP1.0
CNTC Tobacco Science & Technology
Thorne, D., Breheny, D., Gaca, M., Liu, C., Murphy, J., Proctor, C.
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In silico toxicology protocols
Regulatory Toxicology & Pharmacology
Neilson, L. et al
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Integrating chemical, toxicological and clinical research to assess the potential of reducing health risks associated with cigarette smoking through reducing toxicant emissions
Regulatory Toxicology and Pharmacology
McAdam, K., Murphy, J., Eldridge, A., Proctor, C., Meredith, C.
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AIVT Special Issue: Inhalation Toxication
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Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase
Nitric Oxide
Abdelghany, T M., Ismail, R S., Mansoor, F A., Zweier, J R., Lowe, F., Zweier, J L.
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An approach to testing undiluted e-cigarette aerosol in vitro using 3D reconstituted human airway epithelium 
Toxicology In Vitro
Bishop, E., Haswell, L., Adamson, J., Costigan, S., Thorne, D., Gaca, M.
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Optimized method for determination of 16 FDA polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke by gas chromatography–mass spectrometry
Chemistry Central Journal
Jeffery, J., Carradus, M., Songin, K., Pettit, M., Pettit, K., Wright, C.
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Estimation of the Leukemia Risk in Human Populations Exposed to Benzene from Tobacco Smoke Using Epidemiological Data
Risk Analysis
Feibelkorn, S. Meredith, C.
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Extreme testing of undiluted e-cigarette aerosol in vitro using an Ames air-agar-interface technique
Mutation Research
Thorne, D. Hollings, M. Seymour, A. Adamson, J. Dalrymple, A. Ballantyne M. Gaca, M.
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Characterisation of the borgwaldt LM4E system for in vitro exposures to undiluted aerosols from next generation tobacco and nicotine products (NGPs)
Food and Chemical Toxicology
Adamson, J. Jaunky, T. Thorne, D. Gaca, M.
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In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke.
Scientific Reports
Haswell, L. Corke, S. Verrastro, I. Baxter, A. Banerjee, A. Adamson, J. Jaunky, T. Proctor, C. Gaca, M. Minet, E.
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