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Recent publications

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Our Research and Development facility undertakes a variety of research projects using a broad range of scientific disciplines and collaborations.  We publish results from our research in a variety of external, peer-reviewed scientific / academic publications. Here is a brief account of our most recent publications.


Open access manuscripts are indicated with the icon OA

Assessing modified risk tobacco and nicotine products: Description of the scientific framework and assessment of a closed modular electronic cigarette
Regulatory Toxicology and Pharmacology, 2017
Murphy, J. Gaca, M. Lowe, F. Minet, E. Breheny, D. Prasad, K. Camacho, O. Fearon, I. Liu, C. Wright, C. Mcadam, K. Proctor, C.

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A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product
BMC Public Health, 2017
Gale, N., McEwan, M., Eldridge, A., Sherwood, N., Bowen, E., McDermott, S., Holmes, E., Hedge, A., Hossack, S., Camacho, O., Errington, G., McAughey, J., Murphy, J., Liu, C., Proctor, C., Fearon, I.
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A comparative assessment of e-cigarette aerosols and cigarette smoke on in vitro endothelial cell migration
Toxicology Letters, 2017
Taylor, M., Jaunky, T., Hewitt, K., Breheny, D., Lowe, F., Fearon, I., Gaca, M.
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A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency
BMC Genomics, 2017
Edwards, K. D., Fernandez-Pozo, N., Drake-Stowe, K., Humphry, M., Evans, A. D., Bombarely, A., Allen, F., Hurst, R., White, B., Kernodle, S. P., Bromley, J. R., Sanchez-Tamburrino, J.P., Lewis, R.S., Mueller, L.A.
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A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 2): In vitro biological assessment and comparison with different tobacco-heating products
Food and Chemical Toxicology, 2017
Breheny, D., Adamson, J., Azzopardi, D., Baxter, A., Bishop, E., Carr, T., Crooks, I., Hewitt, K., Jaunky, T., Larard, S., Lowe, F., Oke, O., Taylor, M., Santopietro, S., Thorne, D., Zainuddin, B., Gaca, M., Liu, C., Murphy, J.
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A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (part 1): Product operation and preliminary aerosol chemistry assessment
Food and Chemical Toxicology, 2017
Poynton, S., Sutton, J., Goodall, S., Margham, J., Forster, M., Scott, J., Liu, C., McAdam, K., Murphy, J., Proctor, C.
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Comparative tumor promotion assessment of e-cigarette and cigarettes using the in vitro Bhas 42 cell transformation assay
Environmental and Molecular Mutagenesis, 2017
Breheny, D., Oke., O., Pant, K., Gaça, M.
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Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics
Scientific Reports, 2017
Haswell, L., Baxter, A., Banerjee, A., Verrastro, I., Mushonganono, Adamson, J., Thorne, D., Gaça, M., Minet, E.
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An approach to allergy risk assessments for e-liquid ingredients
Regulatory Toxicology and Pharmacology, 2017
Costigan, S., Lopez-Belmonte, J.
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Chemical characterisation of aerosols emitted by electronic cigarettes using thermal desorption – gas chromatography – time of flight mass spectrometry
Journal of Chromatography A, 2017
Rawlinson, C., Martin, S., Frosina, J., Wright, C.
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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Journal of Visualized Experiments (JoVE), 2017
Baxter, A., Minet, E.
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A system dynamics modelling approach to assess the impact of launching a new nicotine product on population health outcomes
Regulatory Toxicology and Pharmacology, 2017
Hill, A., Camacho, O.
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Impact assessment of WHO TobReg proposals for mandated lowering of selected mainstream cigarette smoke toxicants
Regulatory Toxicology and Pharmacology, 2017
Eldridge, A., McAdam, K., Betson, T., Gama, M., Proctor, C.
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Nicotine Quantification In Vitro: A Consistent Dosimetry Marker for e-Cigarette Aerosol and Cigarette Smoke Generation
Applied In Vitro Toxicology, 2017
Adamson, J., Li, X., Cui, H., Thorne, D., Xie, F., Gaça, M.
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Differential Gene Expression Using RNA Sequencing Profiling in a Reconstituted Airway Epithelium Exposed to Conventional Cigarette Smoke or Electronic Cigarette Aerosols
Applied In Vitro Toxicology, 2017
Banerjee, A., Haswell, L., Baxter, A., Parmar, A., Azzopardi, D., Corke, S., Thorne, D., Adamson, J., Mushonganono, J., Gaca M., Minet E.
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Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems
Chemistry Central Journal, 2016
Adamson, J., Thorne, D., Zainuddin, B., Baxter, A., McAughey, J., Gaça, M.
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E-cigarette Nicotine Delivery: Data and Learnings from Pharmacokinetic Studies 
American Journal of Health Behavior, 2016
Fearon, I., Eldridge, A., Gale, N., Shepperd, C., McEwan, M., Camacho, O., Nides, M., McAdam, K., Proctor, C.
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The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2016
Thorne, D., Crooks, I., Hollings, M., Seymour, A., Meredith, C., Gaca, M.
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An Innovative Technique for Rapid Screening of Cigarette Filter Adsorbents
Chemical Engineering & Technology, 2016
Peter Branton, P., Leistner, M., Wöllner, M., Kaskel, S.
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Development, validation and application of a device to measure e-cigarette users’ puffing topography
Scientific Reports, 2016
Cunningham, A., Slayford, S., Vas, C., Gee, J., Costigan, S., Prasad, K.
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